Hitting HIF1 in cancer
نویسندگان
چکیده
منابع مشابه
Cancer cocktails: ABL001 – hitting one target twice
Medicines [2] ABL001 is a small molecule designed to inhibit BCR-ABL, the same protein hit by imatinib and nilotinib, which are used to treat chronic myelogenous leukemia. But ABL001 has a different mechanism of action. It doesn’t bind the active site of its target. Instead it binds a different region of BCR-ABL, forcing a conformational change that disables the protein’s active site. According...
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Tumorigenesis is a complex and multi-factorial process. In the first instance, it requires the accumulation of a series of genetic mutations within preneoplastic cells which uncouple the cells’ normally highly interdependent programmes of growth and differentiation. But oncogenic mutations cannot liberate the expanding tumour population from the need to supply itself with nutrients and oxygen, ...
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Glioblastoma multiforme (GBM) is characterized by extensive angiogenesis that is mostly orchestrated by the hypoxia inducible factor HIF-1. Deregulation of HIF-1 is believed to contribute to cancer initiation and progression. However, instances have been described in which loss of HIF-1 leads to more aggressive tumors. Here we investigated the consequences of downregulating HIF-1 function in th...
متن کاملPrimary tumor vascularity in esophagus cancer. CD34 and HIF1-α expression correlate with tumor progression.
OBJECTIVE Hypoxia inducible factor α (HIF1-α) is a key protein regulating the response of a variety of genes and pathways, including angiogenesis, to hypoxic stimuli. High vascularity in various carcinomas correlates with invasion and metastasis. Assessment of primary tumor vascularity and HIF1-α expression in esophageal carcinomas was an objective of this study. METHODS The vascularity in es...
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Data analysis is used to test the hypothesis that "hitting is contagious". A statistical model is described to study the effect of a hot hitter upon his teammates' batting during a consecutive game hitting streak. Box score data for entire seasons comprising [Formula: see text] streaks of length [Formula: see text] games, including a total [Formula: see text] observations were compiled. Treatme...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2009
ISSN: 1945-3477
DOI: 10.1038/scibx.2009.1461